Solid Form Screening & Selection Centre of Excellence

LGC Solid Form Screening & Selection


Drug Development Solutions' Solid Form Screening and Selection Centre of Excellence builds on our expertise in Materials Science analysis to offer discovery of high quality crystalline forms of small molecule development candidates. Our team has extensive experience in synthetic and medicinal chemistry and will work with you to tailor the screening protocols to maximise hit rate while minimising compound requirement. Selected forms will be resynthesized and fully characterised to ensure the smoothest path into the next stage of development.

Read our SelectScience article: Solid form screening and selection: Why chemistry-led design brings the greatest value to pharmaceutical development


Solid Form Screening

  • Efficient, chemistry led salt screening
  • Polymorph screening
  • Cocrystal design and synthesis
  • Scale up and comprehensive analysis of selected forms
  • Interpretation and recommendation

Solid Form Characterisation

  • Powder X-ray diffraction
  • Differential scanning calorimetry
  • Optical and thermal microscopy
  • Dynamic vapour sorption
  • Thermogravimetric analysis
  • FT-IR
  • NMR

Drug Development Solutions can support you with Solid Form science throughout the drug development process from candidate selection and efficient large scale synthesis through ‘fit for purpose’ formulation and toxicity studies to API and formulated drug substance manufacture.


  • Discovery of crystalline forms
  • Identification of thermodynamically and chemically stable forms
  • IP extensions
  • Hygroscopicity issues
  • Polymorph control
  • Dissolution/solubility limited bioavailability
  • Hydration and solvation issues
  • Synthesis optimisation