Solid Form Screening and Selection Centre of Excellence

LGC Solid Form Screening & Selection

Capabilities

Our expertise in Materials Science analysis includes a solid form screening and selection service to offer discovery of
high-quality crystalline forms for small molecule drug development candidates.

Our team has extensive experience in synthetic and medicinal chemistry and will work with you to tailor the screening protocols to maximise hit rate while minimising compound requirement. Selected forms will be resynthesized and fully characterised to ensure the smoothest path into the next stage of development.

Read our SelectScience article: Solid form screening and selection: Why chemistry-led design brings the greatest value to pharmaceutical development

Solid Form Screening

  • Efficient, chemistry led salt screening
  • Polymorph screening
  • Cocrystal design and synthesis
  • Scale up and comprehensive analysis of selected forms
  • Interpretation and recommendation

Solid Form Characterisation

  • Powder X-ray diffraction
  • Differential scanning calorimetry
  • Optical and thermal microscopy
  • Dynamic vapour sorption
  • Thermogravimetric analysis
  • FT-IR
  • NMR

We can support you with Solid Form science throughout the drug development process from candidate selection and efficient large scale synthesis through ‘fit for purpose’ formulation and toxicity studies to API and formulated drug substance manufacture.

Applications

  • Discovery of crystalline forms
  • Identification of thermodynamically and chemically stable forms
  • IP extensions
  • Hygroscopicity issues
  • Polymorph control
  • Dissolution/solubility limited bioavailability
  • Hydration and solvation issues
  • Synthesis optimisation

Let's discuss your project >